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Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
---------------------------------------------------------------
Author: T Godfraind
Page Count: 325 pages
Published Date: 04 Nov 2011
Publisher: Springer
Publication Country: Dordrecht, Netherlands
Language: English
ISBN: 9789400960350
Download Link: Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
---------------------------------------------------------------
2 The free internal Ca+ concentration in human red cells is set according to the leak- 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca- 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady- 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con- 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec- 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra- tion is;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).
Read online Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions Buy and read online Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions Download Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions for pc, mac, kindle, readers Download to iPad/iPhone/iOS, B&N nook Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions ebook, pdf, djvu, epub, mobi, fb2, zip, rar, torrent
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Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions by T Godfraind
Author: T Godfraind
Page Count: 325 pages
Published Date: 04 Nov 2011
Publisher: Springer
Publication Country: Dordrecht, Netherlands
Language: English
ISBN: 9789400960350
Download Link: Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions
---------------------------------------------------------------
2 The free internal Ca+ concentration in human red cells is set according to the leak- 2 and-pump principle: There is a finite passive Ca+ influx at the physiological 2 2 Ca+ -gradient across the membrane which is compensated by Ca+ pumping in the outward direction with a rate given by the degree of saturation of the A TP-fuelled Ca- 2 pump at the steady-state internal Ca+ concentration. Simons (1982) recently devised a method allowing the measurement of the steady- 2 2 state internal Ca+ concentration. Cells are suspended in media of different Ca+ con- 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec- 2 trode signal. At the point of zero deflection, the cellular Ca+ concentration equals that 2 of the medium. The result is, that in fresh human red blood cells the Ca+ concentra- tion is;;;; O.4,uM (this is an upper estimate; the true value may be considerably lower).
Read online Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions Buy and read online Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions Download Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions for pc, mac, kindle, readers Download to iPad/iPhone/iOS, B&N nook Calcium Entry Blockers in Cardiovascular and Cerebral Dysfunctions ebook, pdf, djvu, epub, mobi, fb2, zip, rar, torrent
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